Turgay İşbir

Yeditepe University, Turkey
Lecture Title: 
"The History of DNA”

• Date of Birth : 30.01.1943
• Adress : Yeditepe University Medical Faculty
İnönü Mah. Kayışdağı Cad 26 Ağustos Yerleşimi 34755 Ataşehir-İstanbul / TURKEY
• Telephone : 0216 578 00 00-1263 / 0533 282 37 26
• E-mail : turgay.isbir@yeditepe.edu.tr , tisbir@superonline.com
• Title : Professor
• Educational Background and Academic Titles :

Bachelor: Faculty of Pharmacy, Ankara University, 1965
PhD: Faculty of Pharmacy-Biochemistry, Ankara University, 1975
Date of Associate Professorship: Medical Faculty- Biochemistry, Çukurova University, 1979
Date of Professorship: , Medical Faculty- Biochemistry, Çukurova University, 1989

• Administrative Function:
• Director of Experimental Medicine Research Institute ( İstanbul University)
• Head of Medical Biology Department (Yeditepe Medical Faculty)
• Head of Department of Molecular Medicine ( Health Science İnstitute)
• Interested Research Fields : Genetic of Cardivascular Diseases, Obesity, Coroner Artery Diseases, Cancer, New Generation Sequencing ( İON TORRENT), Heat Shock Proteins, Antioxidant Systems, Biomarkers.
• Projects: International Projects
• ‘Hem and Globin Synthesis in Infants and Children: Department of Health and Human Sercices Public Health Service’ with Prof.Dr. E.Schwartz.
• NATO –SFS project” TU-GENOTYPES” (ISBN:975-487-048-9) ‘Nato Science For Stability Programme; Selection and Characterization of Cereal Genotypes with High Zinc Efficiency and Evaluation of Bioavailability of zinc in Wheat for the central Anatolian Regions’
• Membership of Scientific Association :
• Membership of Turkish Biochemistry Society,
• Membership of Turkish Hematology Society
• Membership of Turkish Biology and Genetics Society
• Awards : Honorary Membership of Turkish Hematology Society,
Honorary President of Turkish Molecular Medicine Society

12. Publications
Articles Published In International Peer-Reviewed Journals (Articles of SCI Content and not seen in pubmed because of published before 2002)
• Reading HW, İsbir T: Action of lithium on ATPases in the rat iris and visual cortex. Biochem Pharmacol 1 28:23 3471-4, 1979
• Reading HW, İsbir T: The role of cation-activated ATPases in transmitter release from the rat iris. Q J Exp Physiol Cogn Med Sci Apr 65:2 105-16, 1980
• Franklin SG, Wolf SI, Ozdemir Y, Yüregir GT, İsbir T, Blumberg BS: Albumin Naskapi variant in North American Indians and Eti Turks. Proc Natl Acad Sci U S A Sep 77:9 5480-2, 1980
• İsbir T, Unal M, Yesilsoy C, Tukel S: Action of maprotiline on the erythrocyte membrane Na+-K+/Mg++ ATPase and Ca++/Mg++ ATPase in depressed patients. Int J Psychosom 34:2 15-7 ,1987
• Yüregir GT, Donma O, Dikmen N, İsbir T, Cinar M: Population studies of hemoglobin S and other variants in Cukurova, the southern part of Turkey. Acta Haematol 50(4):757-765, 1987.
• Tükel S, İsbir T : Kinetic properties of potassium stimulated ATPase purified from gastric mucosa. Z Naturforsch [C] 43:7-8 609-12, 1988.
• T.İsbir, M.Akbaba, S.Tükel. Effect of commercially available and herbal tea on the red blood cell membrane Na-K ATPase. J. Med. Res. 1(3): 130-133,1990.

• T.Isbir, M.Erkisi, L.Tamer, S.Varınlı, E.Kansu, F.Doran, E.Kahraman. Antitumour effects of Brassica olarecea var. Capitata and its effect on ATPase systems. J Exp Clin Cancer Res. 12(3): 167-172, 1993.
• İsbir T, Tamer L, Taylor A, İsbir M: Zinc, copper and magnesium status in insulin-dependent diabetes. Diabetes Res 26:1 41-5, 1994
• T İsbir, L Tamer, M Erkişi, Y Kekeç, F Doran, S Varınlı, A Taylor. Copper, zinc and magnesium in serum and tissues from patients with carcinoma of breast, stomach and colon. Trace Elements and Electrolytes 12: 198-203, 1994.
• M.Erkişi, R.Turgut, M.Ünsal, T. İspir, S.Varınlı, R.Kılıçoğlu. Adjuvant use of antiprolactin, antiestrogen and cytotoxic chemotherapy for breast cancer. Curr Therapeutic Research. 55(1):67-75, 1994.
• T.Isbir, Y. Kepekci, L.Tamer, G.Yücebilgic, M.Demirtaş, S.Tükel, A.Taylor, M.İsbir. Plasma copperlevels in anklylosing spondilitis patients with cardiovascular complications. Trace Elements and Electrolytes. 11:198-203, 1994.
• T.İsbir, G.Yücebilgic, L.Tamer, F.Baslamili, R.Kocak and A.Taylor. Zinc, copper, magnesium and sickle cell anemia. Trace Elements And Electrolytes. 12(2): 1995.
• Ildan F, Polat S, Göcer AI, Oner A, İsbir T, Mete UO, Kaya M, Karadayi A: The effects of the treatment of intravenous high dose methylprednisolone on Na(+)-K(+)/Mg(+2) ATPase and lipid peroxidation and early ultrastructural findings following middle cerebral artery occlusion in the rat. Surg Neurol 44:6 573-80, 1995
• Ildan F, Oner A, Polat S, İsbir T, Göcer AI, Kaya M, Karadayi: Correlation of alterations on Na(+)-K+/Mg+2 ATPase activity, lipid peroxidation and ultrastructural findings following experimental spinal cord injury with and without intravenous methylprednisolone treatment. Neurosurg Rev 18:1 35-44,1995.
• Itein M, Günay I, Loolu G, İsbir T: Effects of static magnetic field on specific adenosine-5'-triphosphatase activities and bioelectrical and biomechanical properties in the rat diaphragm muscle. Bioelectromagnetics 16:3 147-51, 1995

• Ildan F, Polat S, Oner A, İsbir T, Göçer AI, Tap O, Kaya M, Karadayi A: Effects of naloxone on sodium- and potassium-activated and magnesium-dependent adenosine-5'-triphosphatase activity and lipid peroxidation and early ultrastructural findings after experimental spinal cord injury. Neurosurgery 36:4 797-805 ,1995
• Koçak R, Balamili F, Güvenç B, Tamer L, Aikimbaev KS, İsbir T: Bencyclane as an anti-sickling agent. Br J Haematol 92:2 329-31, 1996
• İsbir T, Yılmaz H, Bihorac A, Akoğlu E: Mild to moderate hypertension and Apolipoprotein E Gene Polymorphism. American Journal of Hypertension. Vol 10.7:827,1997.
• İsbir T, Taylor A, Tamer L. and Kaleağasıoğlu F: Serum selenium levels of children living Adana, Turkey. Trace Elements and Electrolytes Vol 13 :136-137,1996.
• Sönmez H, Süer S, Güngör Z, Kökoğlu E ve İsbir T. Sialidase activities and sialic acid levels of liver and serum from streptozotocin induced diabetic rats. Diabetes Research,1996.
• İsbir T. The Department of Molecular Medicine at the University of Istanbul, Institute of Experimental Medical Research. Molecular Medicine 5: 69-70, 1999
• İsbir T., Yılmaz H., Ağaçhan B., Aydın M., İsbir C.S.: An association between angiotensin converting enzyme gene polymorphism and coronary artery disease. IUBMB Life 48: 205-207, 1999.
• İsbir T, Yaylım İ, Koyuncu H, Ağaçhan B., Zeybek Ü, Aydın M, Araslı M, Yılmaz H., Öztürk O. Inhibition of skin tumorigenesis by brassica oleracea var. capitata, Journal of Balkan Union Oncology 4: 411-415, 1999
• İsbir T, Yaylim I, Aydin M, Ozturk O, Koyuncu H, Zeybek U, Agachan B, Yilmaz H. The effects of Brassica oleraceae var capitata on epidermal glutathione and lipid peroxides in DMBA-initiated-TPA-promoted mice. Anticancer Res. 20(1A):219-24, 2000
• Aydin M, Cengiz S, Agachan B, Yilmaz H, İsbir T. Age-related changes in GM1, GD1a, GT1b components of gangliosides in Wistar albino rats. Cell Biochem Funct 18(1):41-5, 2000
• 27. İsbir T, Agachan B, Yilmaz H, Aydin M.Angiotensin converting enzyme gene polymorphism in Alzheimer's disease. Cell Biochem Funct 18 (2):141-2, 2000
• 28. Ağaçhan B, Yılmaz H, Aydın M, İsbir T. Is there any association between apolipoprotein E and angiotensin converting enzyme gene polymorphism in patients with Parkinson’s disease and dementia in Turkish Population Neurosci Res Com 27:165-173,2000

• 29. Koç. M, Özener IÇ, Tezcan H, Bihorac A, İsbir T, Akoğlu E. Left Ventricular Hypertrophy and Angiotensin Converting Enzyme Gene Polymorphism in Renal Allograft Recipients. Transplant. Proc. 32, 542-544, 2000
• 30. Oztaş B, Erkin E, Dural E, İsbir T. Influence of antioxidants on blood-brain barrier permeability during adrenaline-induced hypertension. Int J Neurosci. 2000 Nov;105(1-4):27-35.
• 31. Öztürk O, Yaylım İ, Aydın M, Yılmaz H, Ağaçhan B, Demiralp E, İsbir T. Increased plasma levels of Interleukin-6 and Interleukin-8 in Thalassemia Major. Haematologia p: 1-8, 2001
• 32. İsbir T, Agachan B, Yilmaz H, Aydin M, Kara I, Eker D, Eker E. Interaction between apolipoprotein-E and angiotensin-converting enzyme genotype in Alzheimer's disease. Am J Alzheimers Dis Other Demen 16(4):205-10, 2001
• 33. Yilmaz H, İsbir T, Agachan B, Aydin M Yilmaz H, İsbir T, Agachan B, Aydin M Is epsilon4 allele of apolipoprotein E associated with more severe end-organ damage in essential hypertension. Cell Biochem Funct 19(3):191-5,2001
• 34. İsbir T, Agachan B, Yilmaz H, Aydin M, Kara I, Eker E, Eker D. Apolipoprotein-E gene polymorphism and lipid profiles in Alzheimer's disease Am J Alzheimers Dis Other Demen 16(2):77-81, 2001
• 35. İldan F, Göçer Aİ, Tuna M, Polat S, Kaya M, İsbir T, Çetinalp E. The effects of the pre-treatment of intravenous nimidiipine on Na+-K+/ Mg+2 ATPase, Ca+2/Mg+2 ATPase, lipid peroxidation and early ultrastructural findings following middle cerebral artery occlusion in the rat. Neurological Research, 23;96-104, 2001.
• 36. Bozkurt N, Ozturk O, İsbir T. New MCAD gene mutation, not previously reported in other nations, found at A1161G in Turkish population. Am J Med Genet. 2001 Oct 15;103(3):255-256.

Articles published in International Peer- Reviewed Journals ( reference PUBMED)

• Yaylım İ, İsbir T. Enhanced Casein Kinase II (CK II ) Activity in Human Lung Tumours Anticancer Research 22 (1A). 215-218, 2002.
• Yaylım İ, İsbir T, Öztürk O, Turna A, Işıtmangil T, Zonüzi F, Çamlıca H. Is There Any Correlation Between Restriction Fragment Length Polymorphism of the L-myc Gene and Metastasis of Non-Small Cell Lung Cancer. Cancer Genetics and Cytogenetics 134 (2): 118-122, Apr15, 2002.
• İsbir T, Yaylım İ, Arıkan S, et al. Increased Frequency Of The S-Allele Of the myc Oncogene In Breast Cancer. Molecular Medicine 8 (9):521-524 Sep 2002.
• İsbir T, Yaylım İ, Arıkan S, et al. Close Correlation Between Restriction Fragment Length Polymorphism Of L-myc gene And Susseptibility To Gastric Cancer. Cancer Det Prev 26 (6): 454-457 2002.
• İsbir T, Yaman A, Yaylım I, et al. Association between Apo B signal peptide gene polymorphism and NIDDM. Cell Biochem Funct 21 (2): 189-190 June 2003.
• Yılmaz H, Ağaçhan B, Isbir T, et al. Is there additional effect of MTHFR C677T Mutation On Lipid Abnormalities İn Renal Allograft Recipients. Transplant P 35 (4): 1390-1392 June 2003.
• İsbir T, Yilmaz H, Ağaçhan B, et al. Cholestrol ester transfer Protein, Apolipoprotein E And lipoprotein Lipase genotypes In Patients With coronary Artery Disease In the Turkish population. Clinical Genetics 64 (3): 228-234 Sep 2003.
• Agachan B, Isbir T, Yilmaz H, Akoglu E. Angiotensin converting enzyme I/D, angiotensinogen T174M-M235T and angiotensin II type 1 receptor A1166C gene polymorphisms in Turkish hypertensive patients. Exp Mol Med. 2003 Dec 31;35(6):545-9.
• Yaylım, İ., N. Işık, N. Bozkurt, H. Yılmaz, S. Arıkan, T. İsbir, “The Apolipoprotein E 4 allele is not a risk factor for Turkish Breast Cancer Patients”, Cancer Genet. Cytogenet.,146, 86-87 (2003).
• Ozturk O, Isbir T, Yaylim I, Kocaturk CI, Gurses A. GST M1 and CYP1A1 gene polymorphism and daily fruit consumption in Turkish patients with non-small cell lung carcinomas. In Vivo. 2003 Nov-Dec;17(6):625-32.

• Hulya Yilmaz, Bedia Agachan, H. Arzu Ergen, Zeynep Ermis Karaali, Turgay Isbir. Methylene Tetrahydrofolate Reductase C677T Mutation And Left Ventricular Hypertrophy In Turkish Patients With Type II Diabetes Mellitus. Journal of Biochemistry and Molecular Biology. 37(2): 234-238, 2004.
• Arzu Ergen H, Hatemi H, Agachan B, Camlica H, İsbir T. Angiotensin-I Converting Enzyme Gene Polymorphism In Turkish Type 2 Diabetic Patients. Exp Mol Med. 2004 Aug 31;36(4):345-350.
• Figen Gürdöl, Elif İşbilen, Hülya Yılmaz, Turgay İsbir, Ahmet Dirican. The association between preeclampsia and angiotensin-converting enzyme insertion/ deletion polymorphism. Clinica Chimica Acta. 2004; 341: 127-131.
• Hülya Yılmaz, Bedia Ağaçhan, Zeynep Ermiş Karaali, Turgay Isbir. Taq1B Polymorphism Of CETP Gene On Lipid Abnormalities In Patients With Type II Diabetes Mellitus. Int J Mol Med. 2004 Jun;13(6):889-93
• Ağaçhan B, Yilmaz H, Karaali Z, İsbir T. Paraoxonase 55 And 192 Polymorphism And Its Relationship To Serum Paraoxonase Activity And Serum Lipids In Turkish Patients With Non-Insulin Dependent Diabetes Mellitus. Cell Biochem Funct. 2004 May-Jun;22(3):163-8.
• Agachan B, Yilmaz H, İsbir T, Akoglu E. Paraoxonase 192 Polymorphism And Its Relationship To Serum Lipids In Turkish Renal Transplant Recipients. Transplantation Proceedings 2004 Jun;36(5):1385-6.
• Zeynep Ermis Karaali, Bedia Agachan, Hulya Yilmaz, Turgay Isbir. Angiotensin Converting Enzyme I/D Gene Polymorphisms And Effects Of Left Ventricular Hypertrophy In Turkish Myocardial Infarction Patients. Acta Cardiol 2004 Oct;59(5):493-7.
• Oktem F, Sirin A, Bilge I, Emre S, Agachan B, Ispir T. ACE I/D gene polymorphism in primary FSGS and steroid-sensitive nephrotic syndrome. Pediatr Nephrol. 2004;19(4):384-9.
• Yilmaz H, Unlucerci Y, Gurdol F, Isbilen E, Isbir T. Association of pre-eclampsia with hyperhomocysteinaemia and methylenetetrahydrofolate reductase gene C677T polymorphism in a Turkish population. Aust N Z J Obstet Gynaecol. 2004 Oct;44(5):423-7.
• Bedia Agachan, Hulya Yilmaz, H.Arzu Ergen, Zeynep Ermis Karaali, Turgay Isbir. Paraoxonase (PON1) 55 and 192 polymorphism and its effects to oxidant-antioxidant system in Turkish Patients with Type 2 Diabetes Mellitus. Physiol Res. 54: 287-293, 2005

• Okay E, Karadenizli A, Müezzinoğlu B, Zeybek U, Ergen HA, İsbir T. N-Acetylcysteine attenuates bacterial translocation after partial hepatoctemy in rats. Journal of Surgical Research. 2005 Aug;127(2):164-70.
• Kafadar AM, Ergen A, Zeybek U, Agachan B, Kuday C, İsbir T. Paraoxonase 192 gene polymorphism and serum paraoxonase activity in high grade gliomas and meningiomas. Cell Biochem Funct 2005; 23: 1–6
• Hekim N, Ergen A, Yaylim I, Yilmaz H, Zeybek U, Ozturk O, İsbir T. No association between MTHFR C677T polymorphism and breast cancer. Cell Biochem Funct. 2007 Jan-Feb;25(1):115-7.
• Umit Zeybek, Bayram Kiran, Turgay Isbir, Kemal Altas . Evaluation of IL-10 and IL-12 effects in LPS-induced septic mice by the determination of intracytoplasmic cytokine. Adv Mol Med 2005; 1(2): 81-86
• Bedia Agachan, C. Selim Isbir, H. Arzu Ergen, Hulya Yilmaz, Ilhan Yaylim, Umit Zeybek, Oguz Ozturk, Turgay Isbir. No association between paraoxonase 192 and 55 polymorphism and increasing risk of coronary artery disease in Turkish patients. Adv Mol Med 2005; 1(2): 92-96
• Yilmaz H, Isbir T, Agachan B, Karaali ZE. Effects of cholesterol ester transfer protein Taq1B gene polymorphism on serum lipoprotein levels in Turkish coronary artery disease patients. Cell Biochem Funct. 2005 Jan-Feb;23(1):23-8.
• Bilge I, Sirin A, Agachan B, Emre S, Sadikoglu B, Yilmaz H, Sucu A, Isbir T. Is paraoxonase 192 gene polymorphism a risk factor for membranoproliferative glomerulonephritis in children? Cell Biochem Funct. 2007 Mar-Apr;25(2):159-65.
• Ali Metin Kafadar, Hulya Yılmaz, Didem Kafadar, Arzu Ergen, Umit Zeybek, Nilufer Bozkurt, Cengiz Kuday, Turgay İsbir. C677T Gene Polymorphısm Of Methylenetetrahydrofolate Reductase (MTHFR) In Meningiomas And High Grade Gliomas. Anticancer Research 26:2445-2450, 2006.
• Biyikli NK, Alpay H, Yildiz N, Agachan B, Ergen A, Zeybek U, Bozkurt N, Ispir T. Paraoxonase 1 192 and 55 polymorphisms in nephrotic children. Pediatr Nephrol 21: 649-654, 2006.

• Yigit B, Bozkurt N, Berber I, Titiz I, Isbir T. Analysis of CC chemokine receptor 5 and 2 polymorphisms and renal transplant survival. Cell Biochem Funct. 2007 Jul-Aug;25(4):423-6.
• Yilmaz H, Isbir S, Agachan B, Ergen A, Farsak B, Isbir T. C677T mutation of methylenetetrahydrofolate reductase gene and serum homocysteine levels in Turkish patients with coronary artery disease. Cell Biochem Funct. 2006 Jan-Feb;24(1):87-90
• Bedia Ağaçhan, İlhan Yaylım, H. Arzu Ergen, Soykan Arıkan, Seden Küçücük, Hülya Yılmaz, S. Ümit Zeybek, Savaş Bayrak, Nilüfer Bozkurt, Uzay Görmüş, Turgay İsbir. Is paraoxonase 1 192 BB genotype risk factor for breast cancer? Adv Mol Med 2006; 2(1): 37-40
• Fehmi Narter, Hülya Yılmaz, Ergin Yücebaş, Feridun Şengör, Nesrin Erçelen, Turgay İsbir. Effects of MDR1 C3435T wobble polymorphism on metastase and tumor stage in prostate cancer . Adv Mol Med 2006; 2(1): 23-28
• Özlem Kurt, Hülya Yılmaz, Turgay İsbir, Hakan Berkkan. Effects of lipoprotein lipase Pvu II gene polymorphism on serum lipoprotein levels in Turkish patients with type 2 diabetes mellitus. Adv Mol Med 2006; 2(1): 41-46
• Umit Zeybek, Turgay Isbir, H Arzu Ergen, Hulya Yılmaz, Nezih Hekim, Emel Akoglu. Effects Of Cholesteryl Ester Transfer Proteın Taq1b Polymorphısm In Renal Transplant Patıents. Transplantation Proceedings 38(5): 1382-1384, 2006.
• Ergen HA, Gormus U, Narter F, Zeybek U, Bulgurcuoglu S, Isbir T. Investigation of NAD(P)H:quinone oxidoreductase 1 (NQO1) C609T polymorphism in prostate cancer. Anticancer Res. 2007 Nov-Dec;27(6B):4107-10.
• Gormus U, Ergen A, Yaylim-Eraltan I, Yilmaz H, Turna A, Bozkurt N, Isbir T. Fas-1377 A/G polymorphism in lung cancer. In Vivo. 2007 Jul-Aug;21(4):663-6.
• Ergen HA, Narter F, Timirci O, Isbir T. Effects of manganase superoxide dismutase Ala-9Val polymorphism on prostate cancer: a case-control study. Anticancer Res. 2007 Mar-Apr;27(2):1227-30.
• Gormus U, Ergen A, Yilmaz H, Dalan B, Berkman S, Isbir T. Fas-1377A/G and FasL-844 T/C gene polymorphisms and epithelial ovarian cancer. Anticancer Res. 2007 Mar-Apr;27(2):991-4.

• Yigit B, Bozkurt N, Narter F, Yilmaz H, Yucebas E, Isbir T. Effects of ACE I/D polymorphism on prostate cancer risk, tumor grade and metastatis. Anticancer Res. 2007 Mar-Apr;27(2):933-6.
• Yaylim-Eraltan I, Arzu Ergen H, Arikan S, Okay E, Oztürk O, Bayrak S, Isbir T. Investigation of the VDR gene polymorphisms association with susceptibility to colorectal cancer. Cell Biochem Funct. 2007 Nov-Dec;25(6):731-7.
• Zeybek U, Yaylim I, Yilmaz H, Ağaçhan B, Ergen A, Arikan S, Bayrak S, Isbir T. Methylenetetrahydrofolate reductase C677T polymorphism in patients with gastric and colorectal cancer. Cell Biochem Funct. 2007 Jul-Aug;25(4):419-22.
• Aydin M, Ozkok E, Ozturk O, Agachan B, Yilmaz H, Yaylim I, Kebabcioglu S, Ispir T. Relationship between interleukin-8 and the oxidant-antioxidant system in end-stage renal failure patients. Exp Clin Transplant. 2007 Jun;5(1):610-3.
• Unür M, Demirez E, Ağaçhan B, Görmüş U, Ergen A, Dalan B, Isbir T. The relationship of oral disturbances of diabetes mellitus patients with paraoxonase gene polymorphisms. Cell Biochem Funct. 2008 Dec;26(8):870-3.
• Dalan AB, Ergen A, Yilmaz H, Karateke A, Isbir T. Manganese superoxide dismutase gene polymorphism, MnSOD plasma levels and risk of epithelial ovarian cancer. J Obstet Gynaecol Res. 2008 Oct;34(5):878-84.
• Tekeli A, Isbir S, Ergen A, Görmüş U, Bozkurt N, Timirci O, Arsan S, Isbir T. APE1 and XRCC3 polymorphisms and myocardial infarction. In Vivo. 2008 Jul-Aug;22(4):477-9.
• Gözü A, Ergen A, Dayicioglu D, Yaylim I, Ozsoy Z, Isbir T. L-myc polymorphism in head and neck nonmelanoma skin and lower lip cancers. Arch Otolaryngol HeadNeck Surg. 2008 Jul;134(7):725-8.
• Yaylim-Eraltan I, Bozkurt N, Ergen A, Zeybek U, Ozturk O, Arikan S, Erbil Y, Uslu I, Camlica H, Isbir T. L-myc gene polymorphism and risk of thyroid cancer. Exp Oncol. 2008 Jun;30(2):117-20.
• Ozger H, Kilicoglu O, Yilmaz H, Ergen HA, Yaylim I, Zeybek U, Isbir T. Methylenetetrahydrofolate reductase C677T gene polymorphism in osteosarcoma and chondrosarcoma patients. Folia Biol (Praha). 2008;54(2):53-7.

• Ergen A, Isbir S, Tekeli A, Isbir T. Investigation of ABCA1 C69T and G-191C polymorphisms in coronary artery disease. In Vivo. 2008 Mar-Apr;22(2):187-90.
• Kalay E, Ergen A, Narter F, Agaçhan B, Görmüs U, Yigit N, Isbir T. ARE-I Polymorphism on PSA Gene in Prostate Cancer Patients of a Turkish Population. Anticancer Res. 2009 Apr;29(4):1395-8.
• Narter KF, Ergen A, Agaçhan B, Görmüs U, Timirci O, Isbir T. Bladder Cancer and Polymorphisms of DNA Repair Genes (XRCC1, XRCC3, XPD, XPG, APE1, hOGG1).Anticancer Res. 2009 Apr;29(4):1389-93.
• Aydogan HY, Isbir S, Kurnaz O, Gormus U, Isbir T. Associations of lipoprotein lipase S447X and apolipoprotein E genotypes with low-density lipoprotein subfractions in Turkish patients with coronary artery disease. In Vivo 2009 Jan-Feb; 23(1):155-61.
• Zejnilovic J, Akev N, Yilmaz H, Isbir T. Association between manganese superoxide dismutase polymorphism and risk of lung cancer. Cancer Genet Cytogenet. 2009 Feb;189(1):1-4.
• Isbilen E., Yılmaz H., Ergen H.A., Unlucerci Y., Isbir T., Gurdol F. Association between paraoxanase 55 and 192 gene polymorphisms on serum homocysteine concentrations in preeclampsia. Folia Biologica (Praha) 55, 35-40 (2009).
• Arpacı A., Görmüş U., Dalan B., Berkman S., İsbir T. Investigation of PON1 192 and PON1 55 Polymorphisms in Ovarian Cancer Patients in Turkish Population. In vivo 23:421-424 (2009).
• Yilmaz A, Emre S, Agachan B, Bilge I, Yilmaz H, Ergen A, Isbir T, Sirin A. Effect of paraoxonase 1 gene polymorphisms on clinical course of Henoch-Schönlein purpura. J Nephrol. 2009 Nov-Dec;22(6):726-32.
• Oztürk O, Kağnici OF, Oztürk T, Durak H, Tüzüner BM, Kisakesen HI, Cakalir C, Isbir T. 192R allele of paraoxanase 1 (PON1) gene as a new marker for susceptibility to bladder cancer. Anticancer Res. 2009 Oct;29(10):4041-6.
• Yaylim-Eraltan I, Ergen A, Görmüs U, Arikan S, Küçücük S, Sahin O, Yigit N, Yildiz Y, Isbir T. Breast cancer and cyclin D1 gene polymorphism in Turkish women. In Vivo. 2009 Sep-Oct;23(5):767-72.

• Attar R, Agachan B, Kucukhuseyin O, Toptas B, Attar E, Isbir T. Association of interleukin 1beta gene (+3953) polymorphism and severity of endometriosis in Turkish women. Mol Biol Rep. 2009 Sep 13.
• Bektas-Kayhan K, Unür M, Yaylim-Eraltan I, Ergen A, Hafiz G, Karadeniz A, Isbir T. Role of L-MYC polymorphism in oral squamous cell carcinoma in Turkey. Anticancer Res. 2009 Jul;29(7):2519-24.
• Agaçhan B, Küçükhüseyin O, Aksoy P, Turna A, Yaylim I, Görmüs U, Ergen A, Zeybek U, Dalan B, Isbir T. Apurinic/apyrimidinic endonuclease (APE1) gene polymorphisms and lung cancer risk in relation to tobacco smoking. Anticancer Res. 2009 Jun;29(6):2417-20.
• Associations of -374T/A polymorphism of receptor for advanced glycation end products (RAGE) gene in Turkish diabetic and non-diabetic patients with coronary artery disease. Kucukhuseyin O, Aydogan HY, Isbir CS, Isbir T. In Vivo. 2009 Nov-Dec;23(6):949-54.
• Is LOX-1 K167N polymorphism protective for coronary artery disease? Kurnaz O, Aydogan HY, Isbir CS, Tekeli A, Isbir T. In Vivo. 2009 Nov-Dec;23(6):969-73.
• Comparison of lipid profiles in relation to APOB EcoRI polymorphism in obese children with hyperlipidemia. Timirci O, Darendeliler F, Bas F, Arzu EH, Umit Z, Isbir T.
In Vivo. 2010 Jan-Feb;24(1):65-9.
• CYP17 (T-34C) and CYP19 (Trp39Arg) polymorphisms and their cooperative effects on breast cancer susceptibility. Tüzüner BM, Oztürk T, Kisakesen HI, Ilvan S, Zerrin C, Oztürk O, Isbir T. In Vivo. 2010 Jan-Feb;24(1):71-4.
• Association between CDKN1A Ser31Arg and C20T gene polymorphisms and colorectal cancer risk and prognosis. Cacina C, Yaylim-Eraltan I, Arikan S, Saglam EK, Zeybek U,
Isbir T. In Vivo. 2010 Mar-Apr;24(2):179-83.
• Association of CCL2 and CCR2 gene variants with endometrial cancer in Turkish women. Attar R, Agachan B, Kuran SB, Cacina C, Sozen S, Yurdum LM, Attar E, Isbir T.
In Vivo. 2010 Mar-Apr;24(2):243-8.
• Neonatal hyperbilirubinemia and G71R mutation of the UGT1A1 gene in Turkish patients. Narter F, Can G, Ergen A, Isbir T, Ince Z, Çoban A. J Matern Fetal Neonatal Med. 2011 Feb;24(2):313-6. doi: 10.3109/14767058.2010.490889. Epub 2010 Jun 8.

• Possible associations of APE1 polymorphism with susceptibility and HOGG1 polymorphism with prognosis in gastric cancer. Canbay E, Agachan B, Gulluoglu M, Isbir T, Balik E, Yamaner S, Bulut T, Cacina C, Eraltan IY, Yilmaz A, Bugra D. Anticancer Res. 2010 Apr;30(4):1359-64.
• Genetic variants of vascular endothelial growth factor and risk for the development of endometriosis. Attar R, Agachan B, Kuran SB, Toptas B, Eraltan IY, Attar E, Isbir T.
In Vivo. 2010 May-Jun;24(3):297-301.
• Effects of myeloperoxidase -463 G/A gene polymorphism and plasma levels on coronary artery disease. Ergen A, İsbir S, Timirci Ö, Tekeli A, İsbir T. Mol Biol Rep. 2011 Feb;38(2):887-91. doi: 10.1007/s11033-010-0181-4. Epub 2010 Jun 22.
• The influence of cyclin D1 A870G polymorphism on colorectal cancer risk and prognosis in a Turkish population. Yaylim-Eraltan I, Arikan S, Yildiz Y, Cacina C, Ergen HA, Tuna G, Görmüs U, Zeybek U, Isbir T. Anticancer Res. 2010 Jul;30(7):2875-80.
• Combined effect of CYP1B1 codon 432 polymorphism and N-acetyltransferase 2 slow acetylator phenotypes in relation to breast cancer in the Turkish population. Ozbek YK, Oztürk T, Tüzüner BM, Calay Z, Ilvan S, Seyhan FM, Kisakesen HI, Oztürk O, Isbir T.
Anticancer Res. 2010 Jul;30(7):2885-9.
• CCND1 and CDKN1B polymorphisms and risk of breast cancer. Canbay E, Eraltan IY, Cercel A, Isbir T, Gazioglu E, Aydogan F, Cacina C, Cengiz A, Ferahman M, Zengin E,
Unal H. Anticancer Res. 2010 Jul;30(7):3093-8.
• Association of monocyte chemotactic protein-1 and CC chemokine receptor 2 gene variants with preeclampsia. Agachan B, Attar R, Isbilen E, Aydogan HY, Sozen S, Gurdol F, Isbir T. J Interferon Cytokine Res. 2010 Sep;30(9):673-6. doi: 10.1089/jir.2010.0008.
• Methylenetetrahydrofolate reductase C677T polymorphism in patients with Henoch-Schönlein purpura. Emre S, Sirin A, Ergen A, Bilge I, Sucu A, Yilmaz A, Isbir T.
Pediatr Int. 2011 Jun;53(3):358-62.
• Association of vitamin D receptor Taq I polymorphism and susceptibility to oral squamous cell carcinoma. Bektas-Kayhan K, Unür M, Yaylim-Eraltan I, Ergen HA, Toptas B, Hafiz G, Karadeniz A, Isbir T. In Vivo. 2010 Sep-Oct;24(5):755-9.

• Paraoxonase 1 192 and 55 polymorphisms in osteosarcoma. Ergen A, Kılıcoglu O, Ozger H, Agachan B, Isbir T. Mol Biol Rep. 2011 Aug;38(6):4181-4.
• Is there any correlation between TNF-related apoptosis-inducing ligand (TRAIL) genetic variants and breast cancer? Yildiz Y, Yaylim-Eraltan I, Arikan S, Ergen HA, Küçücük S, Isbir T. Arch Med Sci. 2010 Dec;6(6):932-6.
• The Association of MTHFR C677T Gene Variants and Lipid Profiles or Body Mass Index in Patients With Diabetic and Nondiabetic Coronary Heart Disease. Kucukhuseyin O, Kurnaz O, Akadam-Teker AB, Isbir T, Bugra Z, Ozturk O, Yilmaz-Aydogan H.J Clin Lab Anal. 2013 Nov;27(6):427-34. doi: 10.1002/jcla.21623.
• Association between FAS and FASL Genetic Variants and Risk of Primary Brain Tumor.
Dalan AB, Timirci-Kahraman O, Turan S, Kafadar AM, Yaylim I, Ergen A, Gormus U, Gulec-Yilmaz S, Kaspar C, Isbir T Int J Neurosci. 2013 Oct 7
• Investigation of the common paraoxonase 1 variants with paraoxonase activity on bone fragility in Turkish patients. Toptaş B, Kurt O, Aydoğan HY, Yaylim I, Zeybek U, Can A, Agachan B, Uyar M, Ozyavuz MK, Isbir T Mol Biol Rep. 2013 Nov;40(11):6519-24. doi: 10.1007/s11033-013-2770-5. Epub 2013 Sep 23.
• The effects of endothelial lipase gene (LIPG) variants on inflammation marker levels and atherosclerosis development. Dalan AB, Toptaş B, Buğra Z, Polat N, Yılmaz-Aydoğan H, Çimen A, Isbir T. Mol Biol Rep. 2013 Aug;40(8):5143-9. doi: 10.1007/s11033-013-2615-2. Epub 2013 May 15.
• CK2 enzyme affinity against c-myc 424-434 substrate in human lung cancer tissue.
Yaylim I, Ozkan NE, Isitmangil T, Isitmangil G, Turna A, Isbir T. Asian Pac J Cancer Prev. 2012;13(10):5233-6.
• Association of vitamin D receptor gene polymorphisms with colon cancer. Gündüz M, Cacına C, Toptaş B, Yaylım-Eraltan İ, Tekand Y, İsbir T. Genet Test Mol Biomarkers. 2012 Sep;16(9):1058-61. doi: 10.1089/gtmb.2012.0044. Epub 2012 Aug 1.
• Decreased IFN-γ and IL-12 levels in panic disorder. Tükel R, Arslan BA, Ertekin BA, Ertekin E, Oflaz S, Ergen A, Kuruca SE, Isbir T. J Psychosom Res. 2012 Jul;73(1):63-7. doi: 10.1016/j.jpsychores.2012.04.012. Epub 2012 May 20.

• Paraoxonase 1 polymorphisms in patients with primary glomerulonephritis: a single-center study in Turkey. Eren Z, Kantarci G, Biyikli N, Arikan H, Tuglular S, Ergen A, Isbir T, Akoglu E. Iran J Kidney Dis. 2012 May;6(3):181-5.
• The exon 3-deleted/full-length growth hormone receptor polymorphism and response to growth hormone therapy in growth hormone deficiency and Turner syndrome: a multicenter study. Baş F, Darendeliler F, Aycan Z, Çetinkaya E, Berberoğlu M, Sıklar Z, Öcal G, Timirci Ö, Çetinkaya S, Darcan Ş, Gökşen Şimşek D, Bideci A, Cinaz P, Böber E, Demir K, Bereket A, Turan S, Atabek ME, Tütüncüler F, Isbir T, Bozkurt N, Kabataş Eryılmaz S, Uzunhan O, Küçükemre Aydın B, Bundak R. Horm Res Paediatr. 2012;77(2):85-93. doi: 10.1159/000335172. Epub 2012 Mar 23.
• Evaluation of ERα and VDR gene polymorphisms in relation to bone mineral density in Turkish postmenopausal women. Kurt O, Yilmaz-Aydogan H, Uyar M, Isbir T, Seyhan MF, Can A. Mol Biol Rep. 2012 Jun;39(6):6723-30. doi: 10.1007/s11033-012-1496-0. Epub 2012 Feb 7.
• Effects of the MTHFR C677T polymorphism on prostate specific antigen and prostate cancer. Küçükhüseyin Ö, Kurnaz Ö, Akadam-Teker AB, Narter F, Yılmaz-Aydoğan H, İsbir T. Asian Pac J Cancer Prev. 2011;12(9):2275-8.
• Investigation of polymorphic variants of PPARD and APOE genes in Turkish coronary heart disease patients. Yılmaz-Aydogan H, Kucukhuseyin O, Kurnaz O, Akadam-Teker B, Kurt O, Tekeli A, Ozturk O, Isbir T. DNA Cell Biol. 2012 May;31(5):867-75. doi: 10.1089/dna.2011.1464. Epub 2012 Jan 25.
• -765 G→C and -1195 A→G promoter variants of the cyclooxygenase-2 gene decrease the risk for preeclampsia. Gurdol F, Cakmakoglu B, Dasdemir S, Isbilen E, Bekpinar S, Isbir T. Genet Test Mol Biomarkers. 2012 May;16(5):435-8. doi: 10.1089/gtmb.2011.0178. Epub 2012 Jan 6.
• Carbonic anhydrase VI exon 2 genetic polymorphism in Turkish subjects with low caries experience (preliminary study). Yarat A, Ozturk LK, Ulucan K, Akyuz S, Atala H, Isbir T. In Vivo. 2011 Nov-Dec;25(6):941-4.

• Is there any association between GLY82 ser polymorphism of rage gene and Turkish diabetic and non diabetic patients with coronary artery disease? Kucukhuseyin O, Yilmaz-Aydogan H, Isbir CS, Isbir T. Mol Biol Rep. 2012 Apr;39(4):4423-8. doi: 10.1007/s11033-011-1230-3. Epub 2011 Sep 25.
• The distribution of exon 3-deleted/full-length growth hormone receptor polymorphism in the Turkish population. Baş F, Keleşoğlu F, Timirci Ö, Kabataş Eryılmaz S, Bozkurt N, Küçükemre Aydın B, Bundak R, Isbir T, Darendeliler F. J Clin Res Pediatr Endocrinol. 2011;3(3):126-31. doi: 10.4274/jcrpe.v3i3.25.
• The LOX-1 3'UTR188CT polymorphism and coronary artery disease in Turkish patients.
Kurnaz O, Akadam-Teker AB, Yilmaz-Aydoğan H, Tekeli A, Isbir T. Mol Biol Rep. 2012 Apr;39(4):4351-8. doi: 10.1007/s11033-011-1222-3. Epub 2011 Sep 7.
• Associations of receptor for advanced glycation end products -374 T/A and Gly82 Ser and peroxisome proliferator-activated receptor gamma Pro12Ala polymorphisms in Turkish coronary artery disease patients. Aydoğan HY, Küçükhüseyin O, Tekeli A, Isbir T.
• Genet Test Mol Biomarkers. 2012 Feb;16(2):134-7. doi: 10.1089/gtmb.2011.0077. Epub 2011 Aug 23. Effects of the PPARG P12A and C161T gene variants on serum lipids in coronary heart disease patients with and without Type 2 diabetes. Yilmaz-Aydogan H, Kurnaz O, Kurt O, Akadam-Teker B, Kucukhuseyin O, Tekeli A, Isbir T. Mol Cell Biochem. 2011 Dec;358(1-2):355-63. doi: 10.1007/s11010-011-0987-y. Epub 2011 Jul 21.
• Paraoxonase-1 192/55 polymorphisms and the risk of lung cancer in a Turkish population. Aksoy-Sagirli P, Cakmakoglu B, Isbir T, Kaytan-Saglam E, Kizir A, Topuz E, Berkkan H. Anticancer Res. 2011 Jun;31(6):2225-9.
• The effect of CYP1A1 and GSTM1 gene polymorphisms in bladder cancer development in a Turkish population. Öztürk T, Kahraman ÖT, Toptaş B, Kisakesen Hİ, Çakalir C, Verim L, Öztürk O, İsbir T. In Vivo. 2011 Jul-Aug;25(4):663-8.
• Comparison of lipid profiles with APOA1 MspI polymorphism in obese children with hyperlipidemia. Toptas B, Görmüş U, Ergen A, Gürkan H, Keleşoglu F, Darendeliler F, Bas F, Dalan AB, Izbirak G, Isbir T. In Vivo. 2011 May-Jun;25(3):425-30.

• MMP2 gene polymorphisms and MMP2 mRNA levels in patients with superficial varices of lower extremities. Görmüş U, Kahraman OT, Isbir S, Tekeli A, Isbir T. In Vivo. 2011 May-Jun;25(3):387-91.
• Polymorphisms in the microsomal epoxide hydrolase gene: role in lung cancer susceptibility and prognosis. Erkisi Z, Yaylim-Eraltan I, Turna A, Görmüs U, Camlica H, Isbir T. Tumori. 2010 Sep-Oct;96(5):756-63.
• The effects of endothelial lipase gene (LIPG) variants on inflammation marker levels and atherosclerosis development. Dalan AB, Toptaş B, Buğra Z, Polat N, Yılmaz-Aydoğan H, Cimen A, Isbir T. Mol Biol Rep. 2013 Aug;40(8):5143-9.
• CK2 enzyme affinity against c-myc 424-434 substrate in human lung cancer tissue. Yaylim I, Ozkan NE, Isitmangil T, Isitmangil G, Turna A, Isbir T. Asian Pac J Cancer Prev. 2012;13(10):5233-6.
• Association of vitamin D receptor gene polymorphisms with colon cancer. Gündüz M, Cacına C, Toptaş B, Yaylım-Eraltan İ, Tekand Y, İsbir T. Genet Test Mol Biomarkers. 2012 Sep;16(9):1058-61.
• Leptin (LEP) and Leptin Receptor ( LEPR) Polymorphism are Related to Body Mass Index (BMI) in Turkish Population. Görmüş U, Timirci-Kahraman Ö, Toptaş B, İsbir T, Çiftçi Ç, Berkkan HH, Daln AB, Karatay MC. Turkish Journal of Medical Science ( accepted) .2013
• The role of mdr1 gene polymorphism in type 2 diabetes mellitus. Karatoprak Ö, Karaali ZE, İncekara K, Çelik F, Zeybek Ü, Ergen A, İsbir T. Turkish Journal of Biochemistry.2013 38(2):186-19
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