Thomas Wieland

Heidelberg University, Germany
Lecture Title: 
"Inhibition of Nucleoside Diphosphate Kinases as a Novel Therapeutic Option in the treatment of Cardiovascular Diseases"

Biographical Sketch

Academic Education

1986-1989 PhD student, Department of Pharmacology, Heidelberg University, Germany
1981-1985 Pharmacy, School of Pharmacy, Heidelberg University, Germany

Scientific Degrees

1996 Venia legendi (Habilitation) in Pharmacology and Toxicology, University of Duis¬burg-Essen, Germany
1989 Dr. rer. nat., Heidelberg University, Germany

Professional Career

since 2018 Head of Department, Experimental Pharmacology, European Center for Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University, Mann¬heim, Germany
2007-2017 Chair and Head, Institute of Experimental and Clinical Pharmacology and Toxicology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Ger¬many
2002-2007 Full Professor, Institute of Experimental and Clinical Pharmacology and Toxicology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Ger¬many
1997-2002 Full Professor,Institute of Experimental and Clinical Pharmacology and Toxi-cology, Hamburg, Germany
1996-1997 Visiting Scientist, Calfornia Institute of Technology, Pasadena, CA, USA
1991-1996 Postdoctoral scholar, Department of Pharmacology, University of Essen, Ger-many
1990-1991 Postdoctoral Scholar, Department of Pharmacology, Heidelberg University, Ger¬many

Honors and Achievements

2019 Deutsche Gesellschaft für Experimentelle und Klinische Pharmakologie und Toxi¬kologie, President
since 2018 Deutsche Gesellschaft für Pharmakologie, President
since 2017 DFG-Fachkollegium Medizin, Sektion 3, Speaker since 2020
2017-2019 DZHK Standort HD/MA, Deputy Speaker
since 2015 Med. Fakultät Mannheim, Dean of Studies
since 2012 Editorial Board, Basic Research in Cardiology
2000 - 2015 Editor, Naunyn-Schmiedeberg’s Archives of Pharmacology
2002-2015 Editorial Board, Methods and Principles in Medicinal Chemistry
2016 Honorary Award Lecture on Basic Science, German Cardiac Society
2003 Albert-Fraenkel-Award, German Cardiac Society

Selection of Key Publications (max. 10)

1. Abu-Taha IH, Heijman J, Hippe HJ, Wolf NM, El-Armouche A, Nikolaev VO, Schafer M, Wurtz CM, Neef S, Voigt N, Baczko I, Varro A, Muller M, Meder B, Katus HA, Spiger K, Vettel C, Lehmann LH, Backs J, Skolnik EY, Lutz S, Dobrev D, Wieland T: Nucleoside diphosphate kinase-C suppresses cAMP formation in human heart failure. Circulation, 135: 881-97, 2017.
2. Zhou XB, Feng YX, Sun Q, Lukowski R, Qiu Y, Spiger K, Li Z, Ruth P, Korth M, Skolnik EY, Borggrefe M, Dobrev D, Wieland T: Nucleoside diphosphate kinase B-activated inter¬mediate conductance potassium channels are critical for neointima formation in mouse carotid arteries. Arterioscler Thromb Vasc Biol, 35: 1852-62, 2015.
3. Feng Y, Gross S, Wolf NM, Butenschön VM, Qiu Y, Devraj K, Liebner S, Kroll J, Skolnik EY, Hammes HP, Wieland T: Nucleoside diphosphate kinase B regulates angiogenesis through modulation of vascular endothelial growth factor receptor type 2 and endo-thelial adherens junction proteins. Arterioscler Thromb Vasc Biol, 34: 2292-300, 2014.
4. Wuertz CM, Lorincz A, Vettel C, Thomas MA, Wieland T, Lutz S. p63RhoGEF-a key mediator of angiotensin II-dependent signaling and processes in vascular smooth muscle cells. FASEB J, 24: 4865-76, 2010.
5. Hippe HJ, Wolf NM, Abu-Taha I, Mehringer R, Just S, Lutz S, Niroomand F, Postel EH, Katus HA, Rottbauer W, Wieland T: The interaction of nucleoside diphosphate kinase B with Gbetagamma dimers controls heterotrimeric G protein function. Proc Natl Acad Sci USA. 106: 16269-74, 2009.
6. Lutz S, Shankaranarayanan A, Coco C, Ridilla M, Nance MR, Vettel C, Baltus D, Evelyn CR, Neubig RR, Wieland T, Tesmer JJ: Structure of Galphaq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs. Science, 318: 1923-7, 2007.
7. Hippe HJ, Luedde M, Lutz S, Koehler H, Eschenhagen T, Frey N, Katus HA, Wieland T, Niroomand F: Regulation of cardiac cAMP synthesis and contractility by nucleoside di¬phos¬phate kinase B/G protein beta gamma dimer complexes. Circ Res, 100: 1191-9, 2007.
8. Cuello F, Schulze RA, Heemeyer F, Meyer HE, Lutz S, Jakobs KH, Niroomand F, Wieland T: Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B and Gbeta subunits. J Biol Chem, 278: 7220-33, 2003.
9. Benndorf R, Böger RH, Ergün S, Steenpass A, Wieland T: Angiotensin II type 2 receptor inhibits vascular endothelial growth factor-induced migration and in vitro tube for¬mation of human endothelial cells. Circ Res, 93: 438-47, 2003.
10. Wieland T, Nürnberg B, Ulibarri I, Kaldenberg-Stasch S, Schultz G, Jakobs KH: Guanine nucleotide-specific phosphate transfer by guanine nucleotide-binding regulatory prot¬ein beta-subunits. Characterization of the phosphorylated amino acid. J Biol Chem, 268: 18111-8, 1993.