Pierre P. D. Kondiah

University of the Withwatersrand, South Africa
Lecture Title: 
“Design and Evaluation of a 3D Bioprinted Implantable Drug Delivery Scaffold for Application in Bone Tissue Engineering”

Dr. Pierre. P. D. Kondiah (Ph.D, Wits) Pharmaceutical Chemistry Lecturer | Researcher Wits Advanced Drug Delivery Platform (WADDP)
University of the Witwatersrand | Dept of Pharmacy and Pharmacology E: pierre.kondiah@wits.ac.za | W: http://www.wits.ac.za/waddp
BIOSKETCH
Dr. Pierre Kondiah is currently a full-time Lecturer of Pharmaceutical Chemistry in the Department of Pharmacy and Pharmacology, University of the Witwatersrand, Johannesburg, South Africa. Dr. Kondiah completed a B. Pharm (Honors) in 2011 in the Department of Pharmacy and Pharmacology, University of Witwatersrand, as a diligent smart student of his class. The B. Pharm (Honors) course undertaken covered both theoretical and practical aspects of pharmacy and pharmacology, such that an in-depth understanding of pharmacological science would be attained. The main aspects of his course covered topics such as developing specific and general laboratory practices; ethical and scientifically sound drug trial development; pharmacodynamics and pharmacokinetics as well as analysis of research techniques and skills. His research project was entitled “Determination of the physicochemical properties of a nano-optic implant.” This was a challenging project implicating experimentation with novel compounds. As of January, 2011; Dr. Kondiah undertook a full- time M. Pharm under supervision of Prof. Viness Pillay in Drug Delivery System Design in the Wits Advanced Drug Delivery Platform, Department of Pharmacy and Pharmacology, University of Witwatersrand. His project entitled “Oral delivery of a biostable/biodegradable Interferon- β nanoformulation for treatment of Multiple Sclerosis”. The primary focus of this research project was the development and testing of a novel drug delivery system which can allow for therapeutically effective absorption of macromolecular (peptide) therapeutics that are traditionally administered parenterally, due to rapid degradation within the gastrointestinal tract. He had chemically synthesized various modified polymers and undertaken a significant amount of bio-mechanical engineering to produce a novel drug delivery system to achieve this aim. Dr. Kondiah has also applied the principles of material science in order to enhance his understanding of the chemical and physical nature of modified polymers. Furthermore, Dr. Kondiah has demonstrated significant understanding in the practical, ethical and scientific principles which govern in vivo research of novel drug delivery systems. After a year of undertaking his Master’s degree, he was upgraded to a PhD degree and completed his project within a year, further publishing research papers in ISI rated journals and filled an international patent for commercialising the advanced technology invented. During this time, he joined the Department of Pharmacy and Pharmacology as a full time staff member, and has been on many committees’ in the faculty of Health Science, for numerous occasions. He currently lecturer’s 3rd year pharmacy students in the subject exit level course of Pharmaceutical Chemistry (PACY 3000) as well as supervising honors and postgraduate students in the field of Advanced Drug Delivery and Pharmaceutical Chemistry. Dr. Kondiah graduated with his Ph.D. in 2015, when he was 25 years of age, demonstrating his goal-orientated abilities, further overcoming obstacles emanating from his research by devising innovative solutions. He has a high level of diligence and integrity, which translates into excellent research as evident by the progress he has currently achieved within his work. Dr. Kondiah has co- authored over 20 peer-reviewed publications in ISI-rated journals to date, a book chapter and secured 2 patent technologies with WADDP. He has presented his research findings at 5 international conferences and has graduated 1 Ph.D. student, which was co-supervised from 2014- 2017 in the field of advanced drug delivery. He has also been award various research grants and awards, most significant being the National Research Foundation of South Africa ‘’Thuthuka Post-Doctoral Research Grant’’ from 2016- 2018.

EDUCATION

Degree
Year
Institution
Title of Research
Doctor of Philosophy
(Acquired at age 25)
2015
University of the Witwatersrand, South Africa
Oral delivery of a biostable and biodegradable Interferon-β nano- formulation for treatment
of Multiple Sclerosis
Bachelor of Pharmacy
(Acquired at age 22)
2011
University of the Witwatersrand, South Africa
-
ACADEMIC AND PROFESSIONAL EXPERIENCE

Position held
Year
Institution
Permanent Staff Lecturer a Wits University
(Appointed at Age 24)
2013-Current
University of the Witwatersrand, Johannesburg, Department of Pharmacy and Pharmacology (Pharmaceutical Chemistry)
Assistant Lecturer
2012-2013
University of the Witwatersrand, Johannesburg, Department of Pharmacy and Pharmacology
Pharmacist Intern
2012-2014
Dis-Chem Pharmacy, Fourways Mall, South Africa
Student Tutor
PROFESSIONAL AFFILIATION

Registered as a Pharmacist Intern with South African Pharmacy Council (P Number: P31923). Registered with the Pharmaceutical Society of South Africa
PROFESSIONAL SYNOPSIS

• South African Pharmacy Council Registration Examinations: Paper 1 (Pharmaceutical Calculations) and Paper 2 (Pharmacy Practice, Pharmacy Administration and Laws relating to Pharmacy Practice). Aggregate result – Competent: July 2012

• South African Pharmacy Council Continuous Professional Development Evaluation: Pharmacy Practice & Pharmacy Administration; Pharmacology & Toxicology; Laws relating to Pharmacy Practice; Pharmaceutics & Pharmaceutical Chem. Aggregate result – Competent: July 2015.

• Bachelor of Pharmacy: University of the Witwatersrand, Johannesburg, Department of Pharmacy and Pharmacology, Honors December 2011.

• Doctor of Philosophy: University of the Witwatersrand, Johannesburg, Department of Pharmacy and Pharmacology. Supervised by Prof. V. Pillay, Prof. Y. E. Choonara and Prof.
G. Modi. Research Title: Oral delivery of a biostable and biodegradable Interferon-β nano- formulation for treatment of Multiple Sclerosis. January 2015.

DUTIES AND RESPONSIBILITIES BEING CARRIED OUT AT WITS UNIVERSITY

1. Undergraduate Teaching: Lecturing Pharmaceutical Chemistry II
Third year Pharmacy students; including conducting and designing of Lab practical’s, drafting of quarterly assignments and 4 examinations for the year, including the final November examination. Other forms of assessments include online quiz’s, and problem solving pharmaceutical chemistry exercises.

2. Administration and Serving on committees
1. FHS Ist Year Working Party (2013-2015)
2. STS Protocol Assessment Committee (2015 to current)
3. Wits Focus Day co-ordinator for Pharmacy (2013-2016)
4. Wits Open Day co-ordinator for Pharmacy (2013-2016)
5. Wits Research Day representative for Pharmacy (2015)

6. Representative researcher at Wits Enterprise for WADDP Research Unit (Currently dealing with overseas partnerships and patent filled agreements) (2015-current)
7. Faculty Research Coordinator for Pharmacy and Pharmacology (2017- current)
8. Wits Medical School admissions committee (2017- current)
9. Professional and Ethical Standards Committee (PESC) (2017- current)
10. Wits Admissions Marketing Task Team (2015- current)

3. Undergraduate research projects co-supervision (Special Project: PACY4003)
1. Stimuli-responsive evaluation of copolymeric copper nano-particles using poly(NIPAM)- eudragit (2015).
2. Synthesis of a nanogel drug delivery system for topical application of muscular skeletal conditions (2015)
3. Design of a pH-responsive system for topical delivery of anti-inflammatories (2016).
4. Rheological analysis of a protein copolymeric system for subcutaneous delivery (2016).
5. Determination of thermo-responsive properties of PEG-PCL copolymer for bone tissue engineering application (2017).
6. Synthesis and evaluation of an implantable drug delivery scaffold for controlled release of methotrexate (2017).
7. Design and physico-chemical evaluation of a 3D-printed scaffold for bone tissue engineering (2018 current study).
8. Evaluation of a bio-stable drug delivery platform for controlled release of interferon beta in multiple sclerosis (2018 current study).

POSTGRADUATE CO-SUPERVISION

Co-supervision of Doctoral student

Completed
M. Siyawamwaya, (Black female), Doctor of Philosophy (Pharmaceutics), upgrade to PhD, full-time, date of commencement in 2015. Research Project: Novel polyelectrolyte complexes for the effective delivery of BCS class II and class IV anti-HIV drugs. Graduated in 2017.

Current
M. Nyoka, (Black male), Doctor of Philosophy (Pharmaceutics), full-time, date of commencement in Jan 2017, in progress. Research Project: The synthesis of cerium oxide nanoparticles coated with a copolymer for super-antioxidant activities for potential treatment of Parkinson’s Disease.

INDIVIDUAL RESEARCH GRANTS
1. National Research Foundation (NRF) of South Africa Thuthuka Post-Doctoral Grant Holder Funding, 2016-2018.
2. FRC Travel Grant to attend APA International Conference on Advanced Polymers, Biomaterials, Bioengineering & Nano Drug Delivery, Date: September 5-7 2016 Venue: Sofitel L'Imperial Resort and Spa, Flic-En-Flac, Mauritius R15,000.00.
3. Vice Chancellors award R15,000,00. 2015.
4. Pharmaceutical Society of South Africa bursary award R30,000.00. 2014.
5. WITS Health Sciences Faculty Research Committee (FRC) Individual Research Grant, R10,000.00, 2013.
6. Postgraduate Merit Award: R22,000.00 (WITS), 2013-2014.
AWARDS AND ACCOLADES
1. Official tutor/mentorship acknowledgment award from the Faculty of Health Science 2010- 2012
2. Gauteng Department of Agriculture and Rural Development (GDARD), 2012 (student award)
3. NRF Scarce skill award 2013 (student award)
4. Wits Innovators Forum First-Time Inventor Award for having disclosed a first patent, Wits Commercial Enterprise (Pty) Ltd., December 2013.
5. Pharmaceutical Society of South Africa Research award, 2014.
5. NRF Grant holder award for post-doctoral research over 3 years, 2016.
6. Elsevier’s Nano Today 2017 Poster Presentation Award, USA, Hawaii.

EXTERNAL MANUSCRIPT REVIEWING RESPONSIBILITIES
AAPS PharmSciTech, International Journal of Pharmaceutics, International Journal of Biological Macromolecules, Carbohydrate Polymers, Pharmaceutical Development and Technology, Journal of Applied Polymer Science, Journal of Controlled Release, Journal of Heterocyclic Chemistry, International Journal of Nutrition and Metabolism, African Journal of Microbiology Research, Archives of Medical research, Biomaterials, Advanced Drug Delivery Reviews, Colloids and Surfaces B: Biointerfaces, European Journal of Medicinal Chemistry, European Journal of Pharmaceutical Sciences, Polymer.

SOFTWARE SPECIALIZATIONS
1. Matlab: Artificial neutral network simulation.
2. Material Studio: Molecular dynamics simulations.
3. Kinetica: Pharmacokinetic and Pharmacodynamic analysis.
4. HyperChem: Molecular mechanics simulations.

PROFESSIONAL AFFILIATIONS

1. South African Pharmacy Council and Medicine Control Council
2. Member of the Pharmaceutical Society of South Africa.
3. Tissue engineering and Regenerative Medicine International Society (TERMIS).

PATENT GRANTED
1. PILLAY Viness, KONDIAH Pierre, DU TOIT Lisa Claire, CHOONARA Yahya Essop, CHOONARA Bibi F, KUMAR Pradeep.
Based on PCT/IB2016/053825
Entitled: AN ORAL PHARMACEUTICAL DOSAGE FORM FOR THE DELIVERY OF A PEPTIDE AND/OR PROTEIN
In the name of: UNIVERSITY OF THE WITWATERSRAND, JOHANNESBURG
Wits Ref: Pillay 40 Dessinc Ref: P1010IN

PROVISIONAL PATENTS APPLIED
SA Provisional Patent Application: 2017/00391, filed 17.01.2017
Inventors: Pariksha Jolene Kondiah, Viness Pillay, Pierre Pavan Demarco Kondiah, Yahya Essop. Choonara, Pradeep Kumar, Lisa Claire. du Toit, Thashree Marimuthu.
Entitled: Treatment of Bone Fractures and Tissue Engineering.

PUBLICATIONS
1. Pierre P.D. Kondiah, Lomas K. Tomar, Charu Tyagi, Yahya E. Choonara, Girish Modi, Lisa
C. du Toit, Pradeep Kumar, Viness Pillay, 2013, A novel pH-sensitive interferon-β (INF-β) oral
delivery system for application in multiple sclerosis, International Journal of Pharmaceutics, 456, 459– 472. Accreditation: ISI; IF: 3.649; Citations: 9.
Contribution: 1st author of the research undertaken in my Masters study. Designed, evaluated and simulated the pH responsive delivery system using a NZW rabbit model. Designed a gastro-resistant protein matrix of which a patent with this technology was filled.

2. Az-Zamakhshariy Zardad, Yahya E. Choonara, Lisa C. du Toit, Pradeep Kumar, Mostafa Mabrouk, Pierre P.D. Kondiah, Viness Pillay, 2016, A Review of Thermo- and Ultrasound- Responsive Polymeric Systems for Delivery of Chemotherapeutic Agents, Polymers 2016, 8, 359; doi:10.3390/polym8100359. Accreditation: ISI; IF: 3.364; Citations: 1.
Contribution: Consulted with the student for determining writing objectives and core principles to be discussed in the paper. Identified key concepts of discussion with the student, and guided the writing with revisions for publication in the journal. Evaluated novel chemotherapeutic properties of formulations to date in the current system of discussion. Drafted various polymers for detailed discussion.

3. Margaret Siyawamwaya, Yahya E. Choonara, Pradeep Kumar, Pierre Kondiah, Lisa C. du Toit, Viness Pillay, 2016, A Humic Acid-Polyquaternium-10 Stoichiometric Self-Assembled Fibrilla Polyelectrolyte Complex: Effect of pH on Synthesis, Characterization and Drug Release, International Journal of Polymeric Materials and Polymeric Biomaterials, 65(11), 550-560. Accreditation: ISI; IF: 1.667; Citations: 1.
Contribution: Co-supervisor of the student, who completed her PhD. Evaluated detailed humic acid-polyquaternium-10 stoichiometric self-assembled fibrilla polyelectrolyte complexes with the student, and assisted with mechanical testing of the polymer for in vivo application. Evaluated microscopic and chemical studies with the student as well as advanced thermal evaluation of the polymer, including the PEC component.

4. Pariksha J. Kondiah, Yahya E. Choonara, Pierre P. D. Kondiah, Thashree Marimuthu, Pradeep Kumar, Lisa C. du Toit, Viness Pillay, 2016, A Review of Injectable Polymeric Hydrogel Systems for Application in Bone Tissue Engineering, Molecules, 21, 1580; doi:10.3390/molecules21111580. Accreditation: ISI; IF: 2.861; Citations: 3.
Contribution: Assisted with publication outline of the paper. Due to my specialization in thermo-responsive polymers, I guided the student with detailed analysis of drug delivery applied polymers for tissue engineering and advanced hydrogel therapeutic systems. Also checked on corrections from the journal and proof reading before final publication.

5. Patrick P. Komane, Yahya E. Choonara, Lisa C. du Toit, Pradeep Kumar, Pierre P. D. Kondiah, Girish Modi, Viness Pillay, 2016, Diagnosis and Treatment of Neurological and Ischemic Disorders Employing Carbon Nanotube Technology, Journal of Nanomaterials, Article ID 9417874, doi:10.1155/2016/9417874. Accreditation: ISI; IF: 1.871; Citations: 0. Contribution: Consulted with the PhD student and guided the project in the selection of pre- formulation studies and characterizations. Contributed to the NMR and FTIR evaluations in the study, as well as detailed discussions on thermal degradation properties of the copolymer system, evaluating the carbon nanotubes for biomedical stability.

6. Simphiwe Mavuso, Yahya E. Choonara, Thashree Marimuthu, Pradeep Kumar, Lisa C. du Toit, Pierre P.D. Kondiah, Viness Pillay, 2016, A dual pH/Redox responsive copper-ligand nanoliposome bioactive complex for the treatment of chronic inflammation, International Journal of Pharmaceutics, 509, 348–359. Accreditation: ISI; IF: 3.649; Citations: 1. Contribution: Consulted with the Masters student regarding pre-formulation studies and employing the design of the Eudragit E100 for pH and redox stimuli responsive properties. Assisted in chemical and mechanical evaluation of the nano-liposomes developed.

7. Yahya E. Choonara, Lisa C. Du Toit, Pradeep Kumar, Pierre P. Kondiah, Viness Pillay,
2016, 3D-printing and the effect on medical costs: a new era? Expert Review of
Pharmacoeconomics & Outcomes Research, 16(1), 23-32. Accreditation: ISI; IF: 1.631;
Citations: 8.
Contribution: Writing the introduction and future outlook of the paper. Also evaluated most recent publications for discussion of new methodologies employing 3D bioprinting in terms of a cost effective technology.

8. Simphiwe Mavuso, Thashree Marimuthu, Pradeep Kumar, Pierre P.D. Kondiah, Yahya E. Choonara, Lisa C. du Toit and Viness Pillay, 2017, In Vitro, Ex Vivo and In Vivo Evaluation of a Dual pH/Redox Responsive Nanoliposomal Sludge for Transdermal Drug Delivery. Journal of Pharmaceutical Sciences. DOI: 10.1016/j.xphs.2017.11.011. Accreditation: ISI; IF: 2.59. Citations: 0.
Contribution: Consulted with the Masters student with in vivo studies using a model for determination of the nano-liposomes for efficient delivery of the transdermal sludge. Evaluated the study by chemical NMR and XRD evaluation, determining key kinetic parameters for optimization of the nano-liposome formulation.

9. Pierre P.D. Kondiah, Lomas K. Tomar, Charu Tyagi, Yahya E. Choonara, Girish Modi, Lisa
C. du Toit, Pradeep Kumar, Viness Pillay, 2017. Development of a Gastric Absorptive, Immediate Responsive, Oral Protein-Loaded Versatile Polymeric Delivery System. AAPS PharmSciTech 18(7):2479-2492. Accreditation: ISI; IF: 2.451. Citations: 1.
Contribution: 1st author of the research undertaken in my PhD study. Completed the study by undertaking chemical and in vivo evaluation using a NZW rabbit model. Concluded results of superior properties for oral protein delivery using insulin, interferon and EPO.

10. Angus Hibbins, Pradeep Kumar, Yahya E. Choonara, Pierre P.D. Kondiah, Lisa C. du Toit Thashree Marimuthu, and Viness Pillay, 2017. Design of a Versatile pH-Responsive Hydrogel for Potential Oral Delivery of Gastric-Sensitive Bioactives. Polymers 9(10):474. Accreditation: ISI; IF: 4.811; Citations:0.
Contribution: Consulted with the PhD student on the synthesis and evaluation of the oral system of proteins, since my speciality lies in the area of oral protein therapeutics. Assisted the researcher with ex vivo and chemical evaluation in the studies, pertaining to FTIR and calcitonin peptide loading. Developed an HPLC method with the researcher for completion of the PhD and publications that followed.

11. Dharmesh Chejara, Mostafa Mabrouk, Pradeep Kumar, Yahya E. Choonara, Pierre P.D. Kondiah, Ravindra V. Badhe, Lisa C. du Toit, Divya Bijukumar and Viness Pillay, 2017. Synthesis and Evaluation of a Sodium Alginate-4-Aminosalicylic Acid Based Microporous Hydrogel for Potential Viscosupplementation for Joint Injuries and Arthritis-Induced Conditions. Marine Drugs 15(8):257. Accreditation: ISI; IF: 3.503; Citations:0. Contribution: Assisted with synthesis of the Sodium Alginate-4-Aminosalicylic Acid hydrogel. Developed optimized evaluations for stress and strain studies undertaken, as well as rheological properties of the hydrogel for visco-supplementation. Guided the Post-Doc with detailed analysis of drug delivery applied for loading and release studies.

12. Pariksha J. Kondiah, Yahya E. Choonara, Pierre P.D. Kondiah, Pradeep Kumar, Thashree Marimuthu, Lisa C. du Toit, Viness Pillay, 2017, Development of an injectable pseudo-bone thermo-gel for application in small bone fractures, International Journal of Pharmaceutics, 520, 39–48. Accreditation: ISI; IF: 3.649; Citations: 0.
Contribution: Assisted with the research project of the PhD student, in terms of synthesis and biological testing of pseudo-bone thermo-gel. The delivery system was thus characterized and evaluated for its biological response to temperature and fracture sealing properties.

13. Ravindra V. Badhe, Divya Bijukumar, Dharmesh R. Chejara, Mostafa Mabrouk, Yahya E. Choonara, Pradeep Kumar, Lisa C. du Toit, Pierre P.D. Kondiah, Viness Pillay, 2017, A composite chitosan-gelatin bi-layered, biomimetic macroporous scaffold for blood vessel
tissue engineering, Carbohydrate Polymers, 157, 1215–1225. Accreditation: ISI; IF: 4.811;
Citations: 4.
Contribution: Assisted researcher with biochemical evaluation of the bi-layered tubular scaffold using FTIR and determination of mechanical properties of the developed scaffold. Cell studies was also supervised and evaluated with the Post-doctoral staff member.

14. Ravindra V. Badhe, Pradeep Kumar, Yahya E. Choonara, Thashree Marimuthu, Olufemi
D. Akilo, Pierre P.D. Kondiah, Lisa C. du Toit, Viness Pillay, 2017, Induction of creep crack morphology in iron oxide microparticles: An outcome of the common-ion effect, Materials Letters, 188, 417–422. Accreditation: ISI; IF: 2.572; Citations: 0.
Contribution: Undertook electron microscopy imaging with the researcher, and consulted with analysis of chemical and stimuli responsive nature of the synthesised drug delivery formulation.

15. Mduduzi Sithole, Yahya E. Choonara, Lisa C. du Toit, Pradeep Kumar, Thashree Marimuthu, Pierre PD Kondiah and Viness Pillay, 2017. Development of a Novel Polymeric Nanocomposite Complex for Drugs with Low Bioavailability. AAPS PharmSciTech 19(1). Accreditation: ISI; IF: 2.451. Citations: 0.
Contribution: Assisted with nano-complexation of the copolymer and sustained drug release optimization with the student. Assisted the student with NMR and XRD evaluation, thereby improving the controlled dynamics of the nano-formulation. Assisted the student with interpretation of chemical and mechanical testing of the nano-particles.

16. Margaret Siyawamwaya, Yahya E. Choonara, Pradeep Kumar, Pierre Kondiah, Lisa C. du Toit, Viness Pillay, 2017. Synthesis, Comparison, and Optimization of a Humic Acid-Quat10 Polyelectrolyte Complex by Complexation-Precipitation versus Extrusion-Spheronization. AAPS PharmSciTech. DOI:10.1208/s12249-017-0803-4. Accreditation: ISI; IF: 2.451. Citations: 0.
Contribution: Co-supervised the student with her PhD project and assisted with pre- formulation and ex vivo studies. Optimized the Humic Acid-Quat10 Polyelectrolyte Complex using DoE studies, and promoted cytotoxicity evaluation and interpretation using caco-2 cell lines.

17. Gretta C. M’bitsi-Ibouily, Thashree Marimuthu, Pradeep Kumar, Lisa C. du Toit,
Yahya E. Choonara, Pierre P. D. Kondiah and Viness Pillay, 2017. Outlook on the Application of Metal-Liganded Bioactives for Stimuli-Responsive Release. Molecules, 22, 2065; doi: 10.3390/molecules22122065. Accreditation: ISI; IF: 2.861. Citations: 0.
Contribution: Preparing the outline of the paper for the student to engage in research progression. Thereafter evaluated the paper and gave the student focus on metal complexes employing stimuli-responsive polymers. I further directed the student and evaluated her PhD review towards chemotherapeutic drug delivery systems for current research applications.

18. Margaret Siyawamwaya, Lisa du Toit, Pierre P. D. Kondiah, Yahya Choonara, Pradeep Kumar and Viness Pillay, 2018. 3D Printed, Controlled Release, Tritherapeutic Tablet Matrix for Advanced Anti-HIV-1 Drug Delivery, European Journal of Pharmaceutics and Biopharmaceutics. Accreditation: ISI; IF: 4.159. Citations: 0.
Contribution: Co-supervised the student with her PhD and assisted with the optimization of 3D-bioprinting for controlled release of the Tritherapeutic Tablet Matrix. I also designed the mechanical testing of the 3D printed tablet, employing a biotester, using micro-imaging for advanced calculations of shear stress and strain on the tablet matrix.

19. Pariksha J. Kondiah, Yahya E. Choonara, Pierre P.D. Kondiah, Pradeep Kumar, Thashree Marimuthu, Lisa C. du Toit, Viness Pillay, 2018. Design, Evaluation and In Silico Analysis of a 3D Bioprinted Pseudo-Bone Drug Delivery Scaffold for Bone Fracture Implantation. International Journal of Biofabrication.
Accreditation: ISI; IF: 4.302. Citations: 0. Pending comments from journal.
Contribution: Assisted with the planning and synthesis of the research project. The PhD student was assisted with 3D bioprinting and biotesting, evaluating the mechanical and physicochemical properties of the controlled release implant for bone tissue engineering.

20. Pierre P.D. Kondiah, Pariksha J. Kondiah, Lisa C. du Toit, Pradeep Kumar, Yahya E. Choonara, Thashree Marimuthu and Viness Pillay, 2018. Nanocomposites for Therapeutic Application in Multiple Sclerosis. In Book Chapter: Applications of Nanocomposite Materials in Drug Delivery. Edited by Dr. V. Inderman. Chapter accepted for publication by Elsevier. Contribution: 1st author of the study, incorporating research undertaken during my PhD study. Completed the study by undertaking cutting edge research in the field of multiple sclerosis, and evaluating means of least invasive treatments for the neurodegenerative condition.

CONFERENCE PRESENTATIONS
1. Pierre Kondiah, Yahya E. Choonara, Pradeep Kumar, Lisa C. du Toit and Viness Pillay, Novel pH sensitive oral Interferon-β delivery system for application in multiple sclerosis. Research at the 36th Annual Conference of the Academy of Pharmaceutical Sciences (APSSA) and the South African Association of Pharmacists in Industry (SAAPI); Abstract no:
103. CedarWood Conference Centre, Sandton, Johannesburg, South Africa, 17-19th September 2015.

2. Margaret Siyawamwaya, Viness Pillay, Yahya E. Choonara, Pradeep Kumar, Pierre P.D. Kondiah and Lisa C. du Toit. Humic acid/polyquaternium-10 novel stoichiometric self- assembled fibrous polyelectrolyte complex. (Poster Presentation). The Academy of Pharmaceutical Sciences of the Pharmaceutical Society of South Africa (APSSA) Conference, Cedar Woods of Sandton, Conference Centre, Johannesburg, South Africa, 2015.

3. Pierre Kondiah, Yahya E. Choonara, Pradeep Kumar, Lisa C. du Toit and Viness Pillay, Development of Versatile Bio-stable Oral Polymeric Delivery Systems for Treatment of MS. APA International Conference on Advanced Polymers, Biomaterials, Bioengineering & Nano Drug Delivery; Sofitel L'Imperial Resort and Spa, Flic-En-Flac, Mauritius, Abstract no:129; September 5-7, 2016.

4. Margaret Siyawamwaya, Viness Pillay, Yahya E. Choonara, Pradeep Kumar, Pierre P.D. Kondiah and Lisa C. du Toit. 3D printing of a novel humic acid and polyquaternium-10 polyelectrolyte complex for controlled oral drug release application. (Poster Presentation). The International AAPS Annual Meeting and Exposition, Colorado Convention Centre, Denver, Colorado, USA, 2016.

5. Margaret Siyawamwaya, Viness Pillay, Yahya E. Choonara, Pradeep Kumar, Pierre P.D. Kondiah and Lisa C. du Toit. The use of a novel polyelectrolyte complex to enhance the aqueous solubility of a BCS class II anti-HIV drug. (Poster Presentation). The Faculty of Health Sciences Research Day, University of the Witwatersrand, Johannesburg, South Africa, 2016.

6. P.P.D Kondiah, Y.E. Choonara, P.J. Kondiah, T. Marimuthu, P. Kumar, L.C. du Toit, V. Pillay. Design and evaluation of a 3D bioprinted implantable drug delivery scaffold for application in bone tissue engineering. 7th International Conference on Mechanics of Biomaterials and Tissues., Waikoloa Hawaii, USA, 10-14th December 2017.

7. P.P.D Kondiah, Y.E. Choonara, P.J. Kondiah, T. Marimuthu, P. Kumar, L.C. du Toit, V. Pillay. Development of an injectable tissue engineered thermo-gel drug delivery system for application in small bone fractures. Elsevier Nano Today, Waikoloa Beach Marriott, Hawaii, USA, December 6-10, 2017.