Claudio Santi

University of Perugia, Italy
Lecture Title: 
"Promising inhibitors targeting Mpro: selenium based compounds with antiSARS-CoV-2 activity"

Prof. Dr. Claudio Santi (FRSC) was born in Fabriano, Italy on July 16, 1967. After finishing his studies of Pharmaceutical Sciences with emphasis on Organic Chemistry at the Perugia University in 1992 he continued with his PhD in Chemical Sciences at the same institution under the guidance of Prof. Marcello Tiecco completing the doctorate in 1996 with distinction. In these years 1996-2002 he was research assistant and moved then to the position of university assistant at the Institute of Organic Chemistry of the same University. This position was interrupted in 1998 for a postdoctoral stay as National Swiss Foundation Fellow in the Thomas Wirth group at The Institut für Organische Chemie, Basel University, Switzerland. In 2010 he was habilitated as associate professor and then promoted to the position of Associate University Professor at the Department of Pharmaceutical Sciences at University of Perugia in 2013. Since the same year he was also habilitated as Full Professor in Organic Chemistry (in the frame of the National Scientific Habilitation(s) 2013 and 2016). He currently leads the group of Catalysis Synthesis and Organic Green Chemistry at the Department of Pharmaceutical Sciences at University of Perugia and the International scientific Network Selenium Sulfur and Redox Catalysis (SeSRedCat). He was visiting professor at The Jan Dlugosz University in Czestochowa in 2013 (receiving in 2018 the title of Honorary Professor of the JDU) in 2014 at Universitade Federal de Pelotas UFPel (Brazil) and in 2020 at The University of Minas Gerais UFMG (Brazil). Since 2017 he is also Fellow of the Royal Society of Chemistry and since 2018 included in the list of “the Top Italian Scientists” (in the section chemistry.

His scientific interests are mainly centered in the chemistry and biochemistry of organoselenium compounds and, in the recent past he developed a series of bioorganic studies for the understanding of the role of selenium in a natural biologic environment and the optimization of new green biomimetic Se-catalyzed synthetic protocols and the development of novel classes of drugable Se-containing compounds. 14 years ago, he reported the preparation of the first class of synthetically successful bench stable zinc selenolates currently named as Santi’s reagents (PhSeZnCl and PhSeZnBr becomes commercially available five years ago). He is author (or co-author) of more than 150 research and review articles, 10 books and books chapters and he is currently editor in chief of Current Chemical Biology and member of the editorial board of several journals among that Molecules (MDPI) and International Journal of Molecular Sciences – section Biochemistry (MDPI).

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